Diagnostic testing for invasive aspergillosis

Invasive aspergillosis is a devastating disease of avian species with both acute and chronic forms. Antemortem diagnostic testing is very problematic. To date, we have implemented and validated a panel of serodiagnostic testing including antibody, galactomannan, and protein electrophoresis. Work is ongoing to study the application of other diagnostic tests and to modify existing tests to improve sensitivity.

Application of acute phase protein testing in the veterinary clinical practice

Considerable publications have demonstrated the utility of major acute phase proteins in animal species. Both diagnostic and prognostic value has been indicated. We are actively collaborating with veterinary specialist practices, zoological institutions, and aquaria to extend these findings in a clinical practice environment.

Effects of fenbendazole treatment on the immune system of rodents

Fenbendazole (FBZ) medicated feed is a key treatment of intestinal parasitic infection in laboratory animals. It is estimated that 40% of rodent colonies in the U.S. have been recently or are currently infected with pinworms. Treatment is labor intensive, lengthy, and expensive but always important due to the potential immune perturbations that may result from unchecked infection. Much consternation is also faced by veterinary resources staff also as they must assure that FBZ will not alter results from ongoing experiments.

Application of acute phase protein quantitation to the detection of disease and stress in laboratory rodents

Acute phase proteins have been proposed as markers of “herd health” in large animals. We seek to examine a similar application in laboratory animals using combinations of serum protein electrophoresis and ELISA. The techniques will be used to assess rodent colony health and environmental changes in the rodent colony.