News : 2013

New Publications on Acute Phase Proteins in Exotic Animals

Acute phase proteins (APP) were first identified in the early 1900’s as early reactants to infectious disease. They are now understood to be an integral part of the acute phase response which is the cornerstone of innate immunity. APP have been shown to be valuable biomarkers as increases can occur with inflammation, infection, neoplasia, stress, and trauma. All animals – from fish to mammals – have demonstrable APP but the type of major APP differs by species. While the primary application of these proteins in a clinical setting is prognostication, studies in animals have demonstrated relevance to diagnosis and detection and monitoring for subclinical disease. APP have been well documented in laboratory, companion, and large animals. It has only been recently that investigations have been initiated in avian, exotic, and wildlife species.

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APP Expression During EEHV Viremia in Asian Elephants

The September issue of the Journal of Zoo and Wildlife Medicine features a study of acute phase protein expression in Asian elephants during elephant endotheliotropic herpesvirus-1 viremia in Asian elephants (Elephas maximus). The study was conducted in the Acute Phase Protein Laboratory at the University of Miami by Dr. Carolyn Cray. Collaborating investigators at the Baylor College of Medicine contributed valuable samples for analysis from elephants in differing periods of infection. The data indicated that EEHV-1 infection does result in acute inflammation and that APP levels may aid in the health monitoring of this species.

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Acute Phase Protein Discussion at ESVCP Day at the ECVIM Meeting

A great opportunity to hear about a wealth of information on the latest on acute phase proteins occurred at the European Society of Veterinary Clinical Pathology day at annual congress of the European College of Veterinary Internal Medicine – Companion Animals. The meeting was held from September 12-14 in Liverpool. The speakers included Dr. Carolyn Cray of the Acute Phase Protein laboratory at the University of Miami who started the session off with a presentation entitled, “Acute Phase Response in Laboratory Animals: Translation to Veterinary and Human Medicine”.

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New Publication on Equine Haptoglobin Quantitation

A new publication on the quantitation and applications of haptoglobin testing in equines can be found in the Article In Press section of Journal of Equine Veterinary Science. This study was completed by Drs. Carolyn Cray and Rodney Belgrave. Samples from 76 clincially normal and abnormal horses were examined for haptoglobin levels. A 3.3-fold statistically significant difference was observed between these groups (p<0.05).

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New Publication on the Application of SAA Testing at a Specialized Equine Practice

A new publication on serum amyloid A (SAA) can be found in the July 1 issue of the Journal of the American Veterinary Medical Association (243:113-119, 2013). This study was completed by Dr. Rodney Belgrave of the Mid-Atlantic Equine Medical Center (Ringoes, NJ) in association with our laboratory. Samples from 212 horses from a specialty veterinary practice were examined using measures including CBC, fibrinogen, serum protein electrophoresis, and SAA. SAA had the highest diagnostic accuracy for the detection of inflammation.

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New Paper on Inflammation in Alpacas

The Acute Phase Protein Laboratory was pleased to have an opportunity to collaborate with Dr. Thomas Passler and his colleagues at the College of Veterinary Medicine at Auburn University on a study recently published in the Journal of Veterinary Internal Medicine. Entitled, “Evaluation of Methods to Improve the Diagnosis of Systemic Inflammation in Alpacas”, Dr. Passler studied the effects of mild systemic inflamation in alpacas, a species well known for its stoicism.

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Clinical Pathology from Penguins to Dolphins

The Georgia Aquarium Research Symposium was held on February 28 – March 1, 2013. This symposium gathered the scientific community to review recent research advances made possible through support from the Georgia Aquarium.

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New Publications on Dolphins

Two new papers have been published regarding protein electrophoresis and acute phase proteins in dolphins. This work was conducted with colleagues at the Georgia Aquarium, Marineland Dolphin Adventure, Harbor Branch Oceanographic Institute at FAU, Dolphin Quest, and NOAA.

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APP Testing for Elephants with EEHV Infection

Dr. Carolyn Cray presented findings from her collaborative work on acute phase protein expression in elephants infected with elephant endotheliotropic herpesvirus (EEHV) at the recent 9th Annual International Workshop held in Houston, Texas. EEHV is the leading cause of death in young elephants under human care and many cases have been confirmed in wild elephants. This infection is a significant threat to the already endangered species.

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