News : 2012 : November

More Info About Equine SAA at 2012 AAEP Meeting

The annual meeting of the American Association of Equine Practitioners in Anaheim provided much insight into equine medicine. Inflammation was a major topic of discussion and there were 2 excellent presentations on the applications of serum amyloid A testing.

Entitled, “Serum Amyloid A and Haptoglobin Concentrations in Pregnant Mares with Experimentally Induced Ascending Placentitis”, Dr. Igor Canisso summarized his preliminary findings on the use of these biomarkers in an important pregnancy model. Both serum amyloid A and haptoglobin levels were observed to increase prior to the development of impending clinical signs. There were no significant changes in the complete blood count or fibrinogen. This work was performed in collaboration with Drs. Barry Ball, Mats Troedsson, and Carolyn Cray (Acute Phase Protein Laboratory, University of Miami).

Entitled, “Effects of Repeated Intra-Articular Administration of Amikacin on Serum Amyloid A, Total Protein, and Nucleated Cell Count in Synovial Fluid From Healthy Horses”, Dr. Andres Sanchez summarized his findings on the use of acute phase proteins in monitoring joint disease. SAA concentrations were previously observed to be elevated in synovial fluid in horses with suspected bacterial joint infection, infectious arthritis, and tenovaginitis (Jacobsen et al., AJVR 67:1738-1742, 2006). This expression was found to be locally induced and not affected by repeated arthrocentesis. In this important control study, Sanchez demonstrated that repeated antibiotic administration alone does not result in an increase in SAA. This again indicates that SAA can be a superior marker to assess these cases.