News : 2014

New Publication on Acute Phase Proteins in Falcons

Check out our collaborators’ new publication on diagnostic tools for the detection of aspergillosis — adult and juvenile falcons were experimentally infected with different dosages of Aspergillus fumigatus. Blood samples were analyzed on day 0 and day 28 for antibody and galactomannan and changes in plasma proteins by protein electrophoresis, haptoglobin, and serum amyloid A.

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New Publication on Hemoglobin Binding Protein in Loggerhead Turtles

This marks the first report of implementation of an assay for hemoglobin binding protein in loggerhead turtles. Eighteen samples reflecting pre and post rehabilitation status were examined by this assay and plasma protein electrophoresis. Significant differences in all analytes were observed between these timepoints and, notably, hemoglobin binding protein levels were found to increase during the rehabilitation period. These results indicate that this assay may serve as a useful tool in assessing the health of sea turtles. As all 7 free ranging sea turtle species have either endangered or threatened status, this new assay may have relevance in the study of wild populations and in monitoring the health status of turtles under human care.

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New Publication on Acute Phase Proteins in Elephants

A new paper is available as early in press in the Journal of Veterinary Diagnostic Investigation which details the first reference intervals for protein electrophoresis and acute phase proteins for the Asian elephant. Results include values from 35 clinically normal animals and 9 animals with clinical problems including pododermatitis, infected tusk, and a traumatic knee injury. While significant differences in some electrophoretic values were present, the specific assay for serum amyloid A was especially sensitive for underlying inflammatory processes offering more than a 5 to 10 fold increase in levels. This acute phase protein should be considered as a health monitoring and prognostic tool in this species.

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New Publication on Acute Phase Proteins in Rhesus Macaques

The first report of acute phase protein expression in rhesus macaques (Macaca mulatta) was published in the recent issue of the Journal of Zoo and Wildlife Medicine. Over 100 samples from clinically healthy animals were examined for serum amyloid A, C reactive protein, and haptoglobin levels resulting in the generation of the first reference intervals for these important biomarkers in this species.

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Acute Phase Protein Presentations at International Society of Animal Clinical Pathology Conference

The 16th biennial conference of the International Society of Animal Clinical Pathology was held in Copenhagen, Denmark in late June. Over 100 attendees were present representing over 24 countries. Great presentations on animal clinical pathology were given with an emphasis on acute phase proteins. Dr. Carolyn Cray, ISACP Scientific Committee Member, gave two presentations.

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New Publication on APP Applications in Equine Placentitis

Bacterial and fungal infections resulting in ascending placentitis are a common cause of late term complications in pregnant mares. Inflammation of the placentus can lead to abortion or premature delivery. Researchers at the Gluck Equine Research Center at the University of Kentucky in Lexington recently published a study acute phase protein expression in an experimental model of bacterial placentitis. Led by Drs. Igor Canisso and Barry Ball, rapid increases in serum amyloid A (SAA) and haptoglobin (HP) were observed after the induction of placentitis and through the point of abortion. These changes were consistently present with the absence of significant changes in fibrinogen and white blood cell counts.

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New Publication on Equine Haptoglobin

A new publication on the quantitation and applications of haptoglobin testing in equines can be found in the recent issue of Journal of Equine Veterinary Science (34(2):337-340, 2014). This study was completed by Drs. Carolyn Cray and Rodney Belgrave. Samples from 76 clincially normal and abnormal horses were examined for haptoglobin levels. A 3.3-fold statistically significant difference was observed between these groups (p<0.05).

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New Publications on Acute Phase Proteins in Manatees and Zebra

The December issue of the Journal of Zoo and Wildlife Medicine includes papers detailing two of our recent collaborations studying the acute phase protein (APP) expression in manatees and zebra. The highly conserved APP, serum amyloid A (SAA), was found to be a major APP of both species. With the determination of normal reference intervals and review of cases from clinically abnormal animals, the APP were found to be sensitive indicators of inflammation with prognostic value. The studies further support that APP are a valuable tool in health assessments in mammals.

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